Wanted: regulatory SNPs

rSNPBase: a database for curated regulatory SNPs

In recent years, human regulatory SNPs (rSNPs) have been widely studied. Here, we present database rSNPBase, freely available at http://rsnp.psych.ac.cn/, to provide curated rSNPs that analyses the regulatory features of all SNPs in the human genome with reference to experimentally supported regulatory elements. In contrast with previous SNP functional annotation databases, rSNPBase is characte...

Identifying causal regulatory SNPs in ChIP-seq enhancers

Thousands of non-coding SNPs have been linked to human diseases in the past. The identification of causal alleles within this pool of disease-associated non-coding SNPs is largely impossible due to the inability to accurately quantify the impact of non-coding variation. To overcome this challenge, we developed a computational model that uses ChIP-seq intensity variation in response to non-codin...

Prediction of functional regulatory SNPs in monogenic and complex disease.

Next-generation sequencing (NGS) technologies are yielding ever higher volumes of human genome sequence data. Given this large amount of data, it has become both a possibility and a priority to determine how disease-causing single nucleotide polymorphisms (SNPs) detected within gene regulatory regions (rSNPs) exert their effects on gene expression. Recently, several studies have explored whethe...

Diagnosis Wanted

Wanted—Skulls

In order to determine the characters of a race, it is necessary that comparison should be made of at least twenty skulls. It is further desirable to have as many of the bones of the skeleton as possible, as comparison of pelvic and long bones give important results in determining race peculiarities. The Hunterian Museum, now under the direction of Professor Flower, F. E. S., is especially inter...